Alka-seltzer plus cold medicine temporarily relieves these symptoms due to a cold: minor aches and pains, headache, runny nose, nasal and sinus congestion, sneezing, sore throat and temporarily reduces fever. Contains: pain reliever, fever reducer, antihistamine and nasal decongestant 36 effervescent tablets Sparkling original formula Adults and children 12 years and over: 2 tablets dissolved in 4 ounce of water